MinEDfind: A Bayesian Design for Minimum Effective Dosing-Finding Trial
The nonparametric two-stage Bayesian adaptive design is a novel phase II clinical trial design for finding the minimum effective dose (MinED). This design is motivated by the top priority and concern of clinicians when testing a new drug, which is to effectively treat patients and minimize the chance of exposing them to subtherapeutic or overly toxic doses. It is used to design single-agent trials.
||Iso, ggplot2, gridExtra
||Chia-Wei Hsu, Fang Wang, Rongji Mu, Haitao Pan, Guoying Xu
||Chia-Wei Hsu <Chia-Wei.Hsu at stjude.org>
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